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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

✍ Scribed by Wang, Xu ;Gong, Xiao-Wei ;Li, Yu-Hua ;Jiang, Yong


Book ID
107472365
Publisher
Higher Education Press and Springer
Year
2010
Tongue
English
Weight
249 KB
Volume
4
Category
Article
ISSN
1673-7342

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A class of inhibitors of mitogen activated protein kinase-activated kinase 2 (MK2) was discovered via high-throughput screening. This compound class demonstrates activity against the enzyme with sub-microM IC(50) values, and suppresses LPS-induced TNFalpha levels in THP-1 cells. MK2 inhibition kinet