Mitochondrial DNA mutations in Leber's optic neuropathy
β Scribed by Orest Hurko
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 122 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0364-5134
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π SIMILAR VOLUMES
## Abstract Patternβreversal visual evoked potentials (VEPs) were measured serially in two brothers with Leber's hereditary optic neuropathy during the active phase of the disease. VEP latency and configuration were normal prior to the onset of visual symptoms. The earliest abnormalities consisted
Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch