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Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease

✍ Scribed by Ana F. Domingues; Daniela M. Arduíno; A. Raquel Esteves; Russell H. Swerdlow; Catarina R. Oliveira; Sandra M. Cardoso

Book ID
113630639
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
543 KB
Volume
45
Category
Article
ISSN
0891-5849

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## Abstract Increasing genetic, pathological, and experimental evidence suggest that neurodegeneration in both familial and sporadic forms of Parkinson's disease (PD) may be related to a defect in the capacity of the ubiquitin–proteasome system (UPS) to clear unwanted proteins, resulting in protein