## Maturity -onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by early onset non-insulin-dependent diabetes mellitus, autosomal dominant inheritance, and primary defect in the function of the beta cells of the pancreas. Mutations in the glucokinase
Missense glucokinase mutation in maturity–onset diabetes of the young and mutation screening in late–onset diabetes
✍ Scribed by Stoffel, M.; Patel, P.; Lo, Y-M.D.; Hattersley, A.T.; Lucassen, A.M.; Page, R.; Bell, J.I.; Bell, G.I.; Turner, R.C.; Wainscoat, J.S.
- Book ID
- 109918199
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 544 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1061-4036
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## Communicated by Mark H. Paalman Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the pancreatic beta-cell sensor. Given its central role in the regulation of insulin release, it is understandab
Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g