## Maturity -onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by early onset non-insulin-dependent diabetes mellitus, autosomal dominant inheritance, and primary defect in the function of the beta cells of the pancreas. Mutations in the glucokinase
Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients
β Scribed by L Vits; D Beckers; M Craen; C De Beaufort; E Vanfleteren; K Dahan; A Nollet; G Vanhaverbeke; SV Imschoot; J-P Bourguignon; V Beauloye; K Storm; G Massa; M Giri; F Nobels; J De Schepper; R Rooman; A Van den Bruel; C Mathieu; W Wuyts
- Book ID
- 110888260
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 101 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0009-9163
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## Maturity -onset diabetes of the young (MODY) resulting from mutations in the glucokinase (GCK) gene accounts for approximately 20% of MODY in the UK. W e have performed fluorescent single stranded conformation polymorphism (F-SSCP) analysis or direct sequencing of the GCK gene in 212 patients re
## Communicated by Mark H. Paalman Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the pancreatic beta-cell sensor. Given its central role in the regulation of insulin release, it is understandab
Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g