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Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients

✍ Scribed by L Vits; D Beckers; M Craen; C De Beaufort; E Vanfleteren; K Dahan; A Nollet; G Vanhaverbeke; SV Imschoot; J-P Bourguignon; V Beauloye; K Storm; G Massa; M Giri; F Nobels; J De Schepper; R Rooman; A Van den Bruel; C Mathieu; W Wuyts


Book ID
110888260
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
101 KB
Volume
70
Category
Article
ISSN
0009-9163

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Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g