## Maturity -onset diabetes of the young (MODY) resulting from mutations in the glucokinase (GCK) gene accounts for approximately 20% of MODY in the UK. W e have performed fluorescent single stranded conformation polymorphism (F-SSCP) analysis or direct sequencing of the GCK gene in 212 patients re
Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients
✍ Scribed by Itziar Estalella; Maria Adelaida Garcia-Gimeno; Alberto Marina; Luis Castaño; Pascual Sanz
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 319 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1435-232X
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## Maturity -onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by early onset non-insulin-dependent diabetes mellitus, autosomal dominant inheritance, and primary defect in the function of the beta cells of the pancreas. Mutations in the glucokinase
The maturity-onset diabetes of the young (MODY), an autosomal dominant form of non-insulin dependent diabetes mellitus (NIDDM), is caused by mutations in the glucokinase (GK, MODY 2) and in the hepatocyte nuclear factor 1 (MODY 3) and 4 (MODY1) genes. We have screened the glucokinase gene by the pol
Maturity-onset diabetes of the young is a genetically heterogenous autosomal dominant form of diabetes mellitus, characterized by an early age at onset and a primary defect in beta-cell function. Forty families with a clinical presentation suggestive of MODY were screened for the most common MODY su