Misonidazole neurotoxicity in rats: Part 11

✍ Scribed by Michael SB Edwards; Deborah G Gordon; Alan Salamy; Victor A Levin; Theodore L Phillips

• Publisher: Springer US
• Year: 1984
• Tongue: English
• Weight: 263 KB
• Volume: 2
• Category: Article
• ISSN: 0167-594X
• DOI: 10.1007/bf00177892

✦ Synopsis

Rats pretreated for 5 days with 50 rag/kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently.