MIR-125b INDUCES ANDROGEN-INDEPENDENT GROWTH OF PROSTATE CANCER CELLS
โ Scribed by Shi, Xu-Bao; Xue, Lingru; Yang, Joy; Evans, Christopher P; deVere White, Ralph W
- Book ID
- 123267801
- Publisher
- Lippincott Williams and Wilkins
- Year
- 2008
- Tongue
- English
- Weight
- 135 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0022-5347
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BACKGROUND. Androgen-independent growth leads to progressive prostate cancer after androgen-ablation therapy. This may be caused by altered specificity of the androgen receptor (AR), by ligand-independent stimulation of the AR, or by paracrine growth modulation by neuropeptides secreted by neuroendo
## BACKGROUND. Differences in gene expression in prostate cells are believed to be secondary to epithelial-stromal interactions. We theorized that bone matrix may provide a fertile "soil" for prostate cancer by inducing androgen-dependent genes and allowing for androgen-independent growth. METHODS