Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
โ Scribed by Feldman, David; Zhao, Xiao-Yan; Malloy, Peter J.; Krishnan, Aruna V.; Swami, Srilatha; Navone, Nora M.; Peehl, Donna M.
- Book ID
- 109828322
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 600 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/76287
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๐ SIMILAR VOLUMES
## Abstract Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgenโdependent to androgenโindependent growth. We use a yeastโbased functional a
## Abstract Androgen and androgen receptor (AR) are involved in growth of normal prostate and development of prostatic diseases including prostate cancer. Androgen deprivation therapy is used for treating advanced prostate cancer. This therapeutic approach focuses on suppressing the accumulation of
## Background A crucial event in Prostate Cancer progression is the conversion from a hormone-sensitive to a hormone-refractory disease state. Correlating with this transition, androgen receptor (AR) amplification and mutations are often observed in patients failing hormonal ablation therapies. ฮฒ-C