Hypoxic-ischemic brain injury in the perinatal period is a major cause of morbidity and mortality. Presently, there are no proven effective therapies with which to safeguard the human neonatal brain against this type of injury. Minocycline, a semisynthetic tetracycline, has been shown to be neuropro
Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model
✍ Scribed by Masahiro Tsuji; Mary Ann Wilson; Mary S. Lange; Michael V. Johnston
- Book ID
- 116458200
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 656 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0014-4886
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## Abstract Minocycline is a second‐generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentio
## Abstract ## Purpose: To develop and compare an automated detection system for ischemic lesions in a neonatal model of bilateral carotid artery occlusion with hypoxia (BCAO‐H) from T2 weighted MRI (T2WI) to the currently used “gold standard” of manual segmentation. ## Materials and Methods: Fo