Hypoxic-ischemic brain injury in the perinatal period is a major cause of morbidity and mortality. Presently, there are no proven effective therapies with which to safeguard the human neonatal brain against this type of injury. Minocycline, a semisynthetic tetracycline, has been shown to be neuropro
Minocycline alleviates hypoxic–ischemic injury to developing oligodendrocytes in the neonatal rat brain
✍ Scribed by Z. Cai; S. Lin; L.-W. Fan; Y. Pang; P.G. Rhodes
- Book ID
- 116787414
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 610 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0306-4522
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## Abstract Minocycline is a second‐generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentio
## Abstract Neonatal hypoxic‐ischemic (HI) white matter injury is a major contributor to chronic neurological dysfunction. Immature oligodendrocytes (OLGs) are highly vulnerable to HI injury. As little is known about in vivo OLG repair mechanisms in neonates, we studied whether new OLGs are generat