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Minocycline: A neuroprotective agent for hypoxic-ischemic brain injury in the neonate?

✍ Scribed by Kathryn M. Buller; Michelle L. Carty; Hanna E. Reinebrant; Julie A. Wixey

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
135 KB
Volume
87
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Minocycline is a second‐generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic‐ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action. © 2008 Wiley‐Liss, Inc.

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