Strategy for lipid suppression in lactate imaging using STIR-DQCT: A study of hypoxic-ischemic brain injury
✍ Scribed by Toshiharu Nakai; William D. Rhine; Tomohisa Okada; David K. Stevenson; Daniel M. Spielman
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 470 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
In vivo lactate detection using gradient enhanced double quantum coherence transfer (DQCT) was significantly improved by addition of short‐time‐inversion‐recovery (STIR). Phantom studies demonstrated lipid suppression down to the background noise level with 33% loss of lactate signal. In vivo studies using a rabbit model of hypoxic and unilateral‐ischemic brain injury showed reduction down to 29 ± 11% in lipids with inversion times between 140 and 170 ms. Lactate signals on the ischemic side were 51 ± 53% higher than the nonischemic side at the peak of hypoxia. STIR‐DQCT can be a useful robust method of obtaining metabolic maps of lactate in vivo.