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Miniaturization of separation techniques using planar chip technology

✍ Scribed by Manz, Andreas ;Verpoorte, Elisabeth ;Effenhauser, Carlo S. ;Burggraf, Norbert ;Raymond, Daniel E. ;Harrison, D. Jed ;Widmer, H. Michael

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 420 KB
Volume: 16
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240160711

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✦ Synopsis

Abstract

Miniaturization of separation columns implies equally reduced vol‐ umes of injectors, detectors, and the connecting channels. Planar chip technology provides a powerful means for the fabrication of micron‐sized structures such as channels. This is demonstrated by two examples. An optical absorbance detector chip exhibits the expected behavior of a 1 mm optical path length cell despite its volume of 1 nL. A capillary electrophoresis device allows integrated injections of 100 pL samples, efficiencies of 70,000 to 160,000 theoretical plates in 10 to 20 seconds, and external laser‐induced fluorescence detection at any capillary length of choice between 5 and 50 mm.

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