Miniaturization of capillary electrophoresis systems using micromachining techniques

✍ Scribed by Ana Mª García Campaña; Willy R. G. Baeyens; Hassan Y. Aboul-Enein; Xinrong Zhang

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 320 KB
• Volume: 10
• Category: Article
• ISSN: 1040-7685
• DOI: 10.1002/(sici)1520-667x(1998)10:4<339::aid-mcs4>3.0.co;2-h

✦ Synopsis

Capillary electrophoresis in its different modes of operation is demonstrated to be a separation technique suitable to be integrated into a planar microdevice. The use of micromachining techniques allows complex capillary geometries to be formed, providing good sensitivity and high separation efficiency when optical detection such as laser-induced fluorescence is coupled. Several research groups and companies have focused their research aims in the development and improvement of microstructures using different substrates and configurations. Although in the last 5 years an important number of publications have been reported in this area, several devices are still in a perfectioning phase. Great promises are offered for the rapid and efficient processing of various types of samples, with fundamental application in biological and clinical assays.