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MINDO/3 calculations of the conformation and carcinogenicity of epoxy-metabolites of aromatic hydrocarbons; 7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

✍ Scribed by G. Klopman; H. Grinberg; A.J. Hopfinger

Book ID
107823396
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
610 KB
Volume
79
Category
Article
ISSN
0022-5193

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## Abstract The reaction of (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene (BP diol epoxide) with DNA, followed by enzymatic hydrolysis and LH 20 Sephadex column chromatography, yielded products containing a purine deoxyribonucleoside linked to a 7,8,9,10‐tetrahydrobenzo(__a