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Mild and Selective Sodium Azide Mediated Cleavage of p -Nitrobenzoic Esters

✍ Scribed by Gómez-Vidal, José A.; Forrester, Michael T.; Silverman, Richard B.


Book ID
121217977
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
39 KB
Volume
3
Category
Article
ISSN
1523-7060

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A mild and selective method for the clea
✍ Randy W Jackson 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 89 KB

A method for the cleavage of t-butyl esters using silica gel in refluxing toluene is reported. Good yields of the corresponding carboxylic acids are obtained, and the reaction is selective for t-butyl esters over t-butyl ethers and trimethylsilylethyl (TMSE) esters.