Mild and efficient reduction of azides to amines: synthesis of fused [2,1-b]quinazolinones
โ Scribed by Ahmed Kamal; K.Venkata Ramana; Hari Babu Ankati; A.Venkata Ramana
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 67 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
FeCl 3 /NaI has been employed for an efficient reduction of a variety of azides. This method is selective in the presence of a nitro functionality and has been extended for the synthesis of fused [2,1-b]quinazolinone ring systems such as deoxyvasicinone.
๐ SIMILAR VOLUMES
Chlorotrimethylsilane -sodium iodide reagent (in situ generation of iodotrimethylsilane)in acetonitrile reduces alkyl and aryl/aroyl azides to the corresponding amines/amides in excellent yields under neutral and mild conditions.
Iodotrimethylsilane: A Mild and Efficient Reagent for the Reduction of Azides to Amines. -An efficient and chemoselective protocol for the reduction of azides using in situ prepared iodotrimethylsilane as a reducing agent is reported. The corresponding amines are formed in excellent yields. -
The reduction of aromatic azido compounds to the corresponding amines with hydriodic acid has been investigated and found to result in high yields. This reductive methodology which proceeds under non refluxing condition has been extended for the synthesis of DNA-interactive pyrrolo[2,1-c][1,4] benzo