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Mild and Chemoselective Peptide-Bond Cleavage of Peptides and Proteins at Azido Homoalanine

✍ Scribed by Jaap Willem Back; Olivier David; Gertjan Kramer; Géraldine Masson; Piotr T. Kasper; Leo J. de Koning; Luitzen de Jong; Jan H. van Maarseveen; Chris G. de Koster


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
250 KB
Volume
44
Category
Article
ISSN
0044-8249

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Mild and Chemoselective Peptide-Bond Cle
✍ Jaap Willem Back; Olivier David; Gertjan Kramer; Géraldine Masson; Piotr T. Kasp 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB

The chemical cleavage of amide (peptide) bonds usually requires harsh conditions. [1] As a result, side reactions and the lack of specificity of chemical amide-bond hydrolysis limits its scope in chemical biology and synthetic applications. Herein, we disclose our results on the selective cleavage o