Mild and Chemoselective Peptide-Bond Cle
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Jaap Willem Back; Olivier David; Gertjan Kramer; Géraldine Masson; Piotr T. Kasp
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Article
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2005
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John Wiley and Sons
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English
⚖ 249 KB
The chemical cleavage of amide (peptide) bonds usually requires harsh conditions. [1] As a result, side reactions and the lack of specificity of chemical amide-bond hydrolysis limits its scope in chemical biology and synthetic applications. Herein, we disclose our results on the selective cleavage o