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Chemical Cleavage of Proteins at Asparaginyl—Glycyl Peptide Bonds

✍ Scribed by Bryan John Smith

Publisher: John Wiley and Sons
Year: 2010
Weight: 24 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200250247

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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The chemical cleavage of amide (peptide) bonds usually requires harsh conditions. [1] As a result, side reactions and the lack of specificity of chemical amide-bond hydrolysis limits its scope in chemical biology and synthetic applications. Herein, we disclose our results on the selective cleavage o