Migration, proliferation, and invasion of human glioma cells following treatment with simvastatin
โ Scribed by Jan Gliemroth; Henryk Zulewski; Hans Arnold; A. Jorge A. Terzis
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 336 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0344-5607
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We have reported high expression of CD44H in human glioma cells. To investigate the role of CD44H in the invasion of human glioma, we established a CD44-anti-sense-gene-expression glioma cell line named U-251AI. The expression of CD44H in the G-4 18-selected U-25 I A l cells was reduced to 2096 of t
## Abstract Malignant gliomas have a tendency to invade diffusely into surrounding healthy brain tissues, thereby precluding their successful surgical removal. Intersectin1 (ITSN1) as a molecular linker in the central nervous system is well known as an important regulator of endocytosis and exocyto