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Microwave-induced by-products in the synthesis of 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile

✍ Scribed by Christelle Lamazzi; Armelle Dreau; Christel Bufferne; Christine Flouzat; Patrick Carlier; Rob ter Halle; Thierry Besson

Book ID: 104096630
Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 231 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.05.068

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✦ Synopsis

The Letter describes the investigation of an industrial reaction of N-methylphenylpiperazine and chloro nicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phe nylpiperazinyl)pyridine-3-carbonitrile (4), extension of the scale leads to unexpected by-products. A specific pathway due to the formation of a reactive 'ionic alkylating intermediate' formed in situ under microwave conditions is proposed to explain the results observed.

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