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Microwave enhanced solution synthesis of 1,4-benzodiazepin-5-ones

✍ Scribed by Vincenzo Santagada; Elisa Perissutti; Ferdinando Fiorino; Beniamino Vivenzio; Giuseppe Caliendo

Book ID
104230229
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
63 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Some 2-methyl-1,4-benzodiazepin-5-ones have been synthesized by the application of microwave irradiation. Conventional heating and microwave irradiation of the reactions were compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced.

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Solid-phase synthesis of 1,5-benzodiazep
Solid-phase synthesis of 1,5-benzodiazepin-2-ones
✍ Matthias K. Schwarz; David Tumelty; Mark A. Gallop πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 269 KB

A solid-phase synthesis ofpolysubstituted 1,5-benzodiazepin-2-ones is described. Resinbound 4-fluoro-3-nitrobanzoic acid was reacted with different ~amino acids, followed by nitro group reduction and formation of the seven-membered ring. Subsequent alkylations at N(5) and N(1) afforded the title com