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Microwave-Assisted Rapid Synthesis of 2,6,9-Substituted Purines
โ Scribed by Huang, He; Liu, Hong; Chen, Kaixian; Jiang, Hualiang
- Book ID
- 125531242
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 58 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1520-4766
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๐ SIMILAR VOLUMES
In an attempt to discover a high-throughput method for the synthesis of 2,6,9-trisubstituted purines, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. A method for microwave-assisted
A method for the combinatorial synthesis of 2,9-substituted purines using a Mitsunobu reaction to alkylate the N-9 position and an arnination reaction to install amines at the C-2 position has been developed.
A simple three-step method for the solution-phase combinatorial synthesis of 2,6,9trisubstituted purines from 2,6-dichloropmine is described. The synthesis exploits the use of resin capture to remove excess reagent used in the f'mal step.