Two different methods for the rapid microwave-assisted amination of halide-functionalized polymers were investigated. Nucleophilic substitution by phthalimide, followed by ring opening with methylamine to liberate the free amine, afforded amino-substituted polymers with up to 76% conversion. The sec
Microwave-assisted preparation of functionalized resins for combinatorial synthesis
โ Scribed by Hao Yang; Yanqing Peng; Gonghua Song; Xuhong Qian
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 87 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A series of functionalized resins were synthesized from Merrifield resin by virtue of microwave irradiation. A significant reduction in reaction time was achieved. This method provides a rapid transformation of functionalized resin in solid-phase synthesis.
๐ SIMILAR VOLUMES
A new highly efficient MICROCOS technology (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The ad