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Microwave assisted combinatorial chemistry synthesis of substituted pyridines

✍ Scribed by Ian C. Cotterill; Alexander Ya. Usyatinsky; John M. Arnold; Douglas S. Clark; Jonathan S. Dordick; Peter C. Michels; Yuri L. Khmelnitsky

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
288 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new highly efficient MICROCOS technology (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The advantages of microwave-assisted chemistry for combinatorial synthesis include a broad range of available chemistries, simple reaction setup and product recovery readily amenable to automation, extremely short reaction times, and high product yields.

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