✦ LIBER ✦

Microstructural white matter changes in primary torsion dystonia

✍ Scribed by Maren Carbon; Peter B. Kingsley; Chengke Tang; Susan Bressman; David Eidelberg

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 239 KB
Volume: 23
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21806

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT‐MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello‐thalamo‐cortical pathways as a cause of the clinical manifestations of PTD. © 2007 Movement Disorder Society

📜 SIMILAR VOLUMES

Microstructural white matter changes in

Microstructural white matter changes in carriers of the DYT1 gene mutation

✍ Maren Carbon; Peter B. Kingsley; Sherwin Su; Gwenn S. Smith; Phoebe Spetsieris; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB 👁 2 views

## Abstract We tested the hypothesis that the DYT1 genotype is associated with a disorder of anatomical connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic resonance imaging (DTI) to assess the microstructure of white matter pathways in mutation carriers and

Voxel based morphometry reveals specific

Voxel based morphometry reveals specific gray matter changes in primary dystonia

✍ Karl Egger; Joerg Mueller; Michael Schocke; Christian Brenneis; Martina Rinnerth 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

## Abstract The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel‐based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dyst

Comparing endophenotypes in adult-onset

Comparing endophenotypes in adult-onset primary torsion dystonia

✍ David Bradley; Robert Whelan; Richard Walsh; John O'Dwyer; Richard Reilly; Siobh 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB

## Abstract Adult‐onset primary torsion dystonia (AOPTD) has an autosomal dominant pattern of inheritance with markedly reduced penetrance; the genetic causes of most forms of AOPTD remain unknown. Endophenotypes, markers of sub‐clinical gene carriage, may be of use detecting non‐manifesting gene c

Familial tremulous and myoclonic dystoni

Familial tremulous and myoclonic dystonia with white matter changes in brain magnetic resonance imaging

✍ Dr. S. Bohlega; B. Stigsby; M. Z. Al-Kawi; D. R. McLean; P. Ozand; S. Omer; P. C 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 496 KB 👁 1 views

## Abstract We report two families with a disorder, probably autosomal recessive, characterized by tremor of juvenile onset, dystonia, and myoclonus with preserved cognitive, cerebellar, and peripheral nervous system functions. During 4 years' follow‐up, mild spasticity appeared. Magnetic resonance

Structural white matter abnormalities in

Structural white matter abnormalities in patients with idiopathic dystonia

✍ Leonardo Bonilha; Paulien M. de Vries; Diana J. Vincent; Chris Rorden; Paul S. M 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB

## Abstract We investigated whether structural white matter abnormalities, in the form of disruption of axonal coherence and integrity as measured with diffusion tensor imaging (DTI), constitute an underlying pathological mechanism of idiopathic dystonia (ID), independent of genotype status. We stu

Age-related microstructural changes in s

✍ Takashi Yoshiura; Tomoyuki Noguchi; Akio Hiwatashi; Osamu Togao; Koji Yamashita; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 534 KB

## Abstract Continuous maturation of cerebral white matter (WM) in the postadolescent period is not fully understood. To elucidate the time course and location of possible postadolescent maturational changes in cerebral WM, we studied 60 healthy male subjects who were in their second to seventh dec