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Voxel based morphometry reveals specific gray matter changes in primary dystonia

✍ Scribed by Karl Egger; Joerg Mueller; Michael Schocke; Christian Brenneis; Martina Rinnerthaler; Klaus Seppi; Thomas Trieb; Gregor K. Wenning; Mark Hallett; Werner Poewe

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 95 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21619

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✦ Synopsis

Abstract

The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel‐based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dystonia (FHD) as well as 31 age and gender‐matched controls were included. When compared with healthy controls, patients with primary dystonia (n = 31) showed gray matter volume increase bilaterally in the globus pallidus internus, nucleus accumbens, prefrontal cortex, as well as unilaterally in the left inferior parietal lobe. This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes. © 2007 Movement Disorder Society

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