## Abstract ## Background. Microsomal epoxide hydrolase (mEH) is an enzyme involved in the metabolism of (pre)carcinogens in tobacco smoke. We investigated whether functional genetic polymorphisms in mEH may have a riskβmodifying effect on head and neck carcinogenesis. ## Methods. Blood from 429
Microsomal epoxide hydrolase genotype and risk of myocardial infarction
β Scribed by Marilyn C. Cornelis; Ahmed El-Sohemy; Hannia Campos
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 246 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0340-5761
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## Abstract Microsomal epoxide hydrolase (mEPHX) is a critical metabolic enzyme involved in the activation and subsequent detoxification of specific tobacco carcinogens. __mEPHX__ harbors polymorphisms in exon 3 and exon 4 that modulate enzymatic activity. The exon 3 polymorphism decreases mEPHX me
Microsomal epoxide hydrolase (EPHX) is one of many enzymes involved in the metabolism of endogenous and exogenous toxicants. Polymorphic forms of the human EPHXgene have been described that vary in enzymatic activity, and one, Tyrl13His, has been associated with hepatocellular carcinoma susceptibili
The effects of tienilic acid [ 2,3-dichloro-4-(2-thienylcarbonyl)phenoxy acetic acid] on drug-metabolizing enzymes in the rat liver and kidneys were studied. Short-term treatment for 2 weeks (450 mg per kg per day) increased the activity of microsomal epoxide hydrolase at least two-fold in both rat