𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer

✍ Scribed by Martin Lacko; Hennie M. J. Roelofs; Rene H. M. te Morsche; Adri C. Voogd; Michael B. Oude Ophuis; Wilbert H. M. Peters; Johannes J. Manni

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
110 KB
Volume
30
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Microsomal epoxide hydrolase (mEH) is an enzyme involved in the metabolism of (pre)carcinogens in tobacco smoke. We investigated whether functional genetic polymorphisms in mEH may have a risk‐modifying effect on head and neck carcinogenesis.

Methods.

Blood from 429 patients with oral, pharyngeal, and laryngeal carcinoma and 419 healthy subjects was investigated for mEH polymorphisms.

Results.

Logistic regression analysis did not show differences in mEH genotype distributions between patients and controls, when categorized according to predicted mEH enzyme activity. Also no differences were found when evaluated according to tumor localization, sex, or tobacco consumption. A significantly higher incidence of the 139Arg/Arg variant was found in patients with hypopharyngeal carcinoma compared with controls (OR = 4.39, 95% CI = 1.45 to 13.35).

Conclusion.

In contrast to earlier reports, we could not demonstrate a risk‐modifying effect of genetic polymorphisms in mEH on head and neck carcinogenesis, except for the predicted high activity variant in patients with hypopharyngeal carcinoma. Β© 2008 Wiley Periodicals, Inc. Head Neck 2008

πŸ“œ SIMILAR VOLUMES

Microsomal epoxide hydrolase polymorphis
Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer
✍ Johnathan M. Lancaster; Heather A. Brownlee; Douglas A. Bell; P. Andrew Futreal; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 503 KB

Microsomal epoxide hydrolase (EPHX) is one of many enzymes involved in the metabolism of endogenous and exogenous toxicants. Polymorphic forms of the human EPHXgene have been described that vary in enzymatic activity, and one, Tyrl13His, has been associated with hepatocellular carcinoma susceptibili

Microsomal epoxide hydrolase polymorphis
Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-Hispanic whites
✍ Hua Zhao; Margaret R. Spitz; Karin M. Gwyn; Xifeng Wu πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 91 KB

## Abstract Microsomal epoxide hydrolase (mEPHX) is a critical metabolic enzyme involved in the activation and subsequent detoxification of specific tobacco carcinogens. __mEPHX__ harbors polymorphisms in exon 3 and exon 4 that modulate enzymatic activity. The exon 3 polymorphism decreases mEPHX me

Meta-analysis of glutathione S-transfera
Meta-analysis of glutathione S-transferase M1 genotype and risk toward head and neck cancer
✍ Chandra B. Tripathy; Nilanjan Roy πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 132 KB πŸ‘ 2 views

Background. We sought to evaluate the estimated risk of GSTM1 null genotype and squamous cell carcinoma of the head and neck (SCCHN). Methods. The studies done so far for GSTM1 null genotype as a risk factor associated with head and neck cancer are not conclusive and have shown conflicting results.

COX-2 polymorphisms and the risk for hea
COX-2 polymorphisms and the risk for head and neck cancer in white patients
✍ Wilbert H. M. Peters; Martin Lacko; Rene H. M. te Morsche; Adri C. Voogd; Michae πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 90 KB πŸ‘ 1 views

## Abstract ## __Background.__ Cyclooxygenase‐2 (COX‐2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of processes such as inflammation, cell proliferation, and angiogenesis, all relevant for cancer development. We investigated whether functional g