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Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer

✍ Scribed by Johnathan M. Lancaster; Heather A. Brownlee; Douglas A. Bell; P. Andrew Futreal; Jeffrey R. Marks; Andrew Berchuck; Roger W. Wiseman; Jack A. Taylor

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
503 KB
Volume
17
Category
Article
ISSN
0899-1987

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✦ Synopsis

Microsomal epoxide hydrolase (EPHX) is one of many enzymes involved in the metabolism of endogenous and exogenous toxicants. Polymorphic forms of the human EPHXgene have been described that vary in enzymatic activity, and one, Tyrl13His, has been associated with hepatocellular carcinoma susceptibility. We demonstrated that EPHXwas highly expressed in the human ovary, and investigated whether specific EPHXgenotypes are associated with ovarian cancer susceptibility. Seventy-three Caucasian patients with ovarian cancer and 75 Caucasian-female controls without cancer were genotyped for t h e Tyrl13His polymorphism by a polymerase chain reaction-restriction fragment length polymorphism assay. The frequency of t h e homozygous high-activity genotype was 41 % in the control population and 64% in the ovarian cancer patients. The odds ratio for ovarian cancer with this genotype was 2.6 (95% confidence interval 1.3, 5.0; P c 0.01). The increased ovarian cancer risk associated with the high-activity genotype could reflect differences in metabolic activation of endogenous or exogenous carcinogens.

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