Microsatellite instability in multiple gastric cancers

✍ Scribed by Hideaki Nakashima; Masayuki Honda; Hiroshi Inoue; Kenji Shibuta; Shinya Arinaga; Shoichi Era; Hiroaki Ueo; Masaki Mori; Tsuyoshi Akiyoshi

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: French
• Weight: 636 KB
• Volume: 64
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910640405

✦ Synopsis

To better elucidate the role of genetic instability in the development of gastric cancer, microsatellite alterations were examined in a total of 30 gastric cancers that developed in 14 Japanese patients with multiple gastric cancers, which are considered to have possibly occurred under the same genetic background and in the same microenvironment of the stomach.

Microsatellite instability (MSI) in multiple gastric cancers was recognized in I I out of 14 cases (78.5Oh) and in 16 out of 30 cancers (53.3%). Eight out of I I cases showing MSI exhibited a heterogeneity of microsatellite alterations. The incidence of microsatellite instability in the multiple gastric cancers cases was significantly higher than that in the solitary gastric cancer cases reported previously (20.8%: 5 out of 24 cases). These results suggested that (I) genetic instability plays a more