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Microsatellite instability in sporadic human breast cancers

✍ Scribed by Tatsuya Toyama; Hirotaka Iwase; Hiroko Yamashita; Hiroji Iwata; Toshinari Yamashita; Kazuko Ito; Yasuo Hara; Mariko Suchi; Taiji Kato; Takaaki Nakamura; Shunzo Kobayashi

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 486 KB
Volume: 68
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19961115)68:4<447::aid-ijc8>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

Human breast-cancer specimens from 100 patients were analyzed for microsatellite instability (referred to as replication error; RER) at I 2 genomic loci on 7 chromosomes, and results were correlated with clinicopathologic characteristics. In 42 of I00 breast-cancer patients, we investigated whether RER was associated with the amplification of oncogenes and/or suppmsion of tumor-suppressor genes. Of the 100 patients, 8 (8%) were RER-positive at one or more chromosomal loci. The majority of RER-positive patients had early-stage disease with ER-positive tumors, suggesting that RER occurs early in breast tumorigenesis. However, no significant correlation was observed between RER and oncogenes or tumor-suppressor genes. Thus, the mechanism of RER in sporadic human breast cancer may be independent of the multi-step minogenesis caused by the alterations of oncogenes and tumor-suppressor genes.

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