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Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation

✍ Scribed by Masahiro Hayashi; Gen Tamura; Zhe Jin; Izumi Kato; Makoto Sato; Yoichiro Shibuya; Suran Yang; Teiichi Motoyama


Book ID
114431247
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
180 KB
Volume
53
Category
Article
ISSN
1320-5463

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Promoter hypermethylation profile of tum
✍ Muthusamy Viswanathan; Nobuo Tsuchida; Govindaswamy Shanmugam πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 211 KB

## Abstract Aberrant promoter hypermethylation of tumor‐associated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restriction‐multiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __E‐cad__ genes in