## Abstract Mitochondrial DNA (mtDNA) large deletions and mtDNA mutations have been demonstrated in various types of human cancer. The relationship between the occurrence of such alterations and the nuclear microsatellite instability (MSI) status of the neoplastic cells remains controversial. In an
✦ LIBER ✦
Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma
✍ Scribed by Wataru Habano; Tamotsu Sugai; Shin–Ichi Nakamura; Noriyuki Uesugi; Toru Yoshida; Shunichi Sasou
- Book ID
- 119423963
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 146 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Gastric carcinoma is one of the most common types of cancer in Taiwan. Somatic mitochondrial DNA (mtDNA) alteration in gastric carcinoma and its association with clinicopathologic features remain unclear. When we used polymerase chain reaction (PCR) and direct sequencing, 15 of the 31 (