Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred
Microsatellite Instability and Expression of MLH1 and MSH2 in Normal and Malignant Endometrial and Ovarian Epithelium in Hereditary Nonpolyposis Colorectal Cancer Family Members
β Scribed by Yoshihito Ichikawa; Stephen J Lemon; Shuhe Wang; Barbara Franklin; Patrice Watson; Joseph A Knezetic; Chhanda Bewtra; Henry T Lynch
- Book ID
- 114136890
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 721 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0165-4608
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## Abstract HNPCC is an autosomal dominantly inherited cancerβsusceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract
## Genetic diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC ) may have a significant impact on the clinical management of patients and their at-risk relatives. At present, clinical criteria represent the simplest and most useful method for the identification of HNPCC families and for