Multiple hemi-and homozygous interstitial deletions at chromosome 3p have been found in different types of cancer, including non-papillary renal cell carcinoma (RCC). To determine the frequency and size of deletions, we have analyzed paired normal and tumor DNA obtained from short-term cultures of 1
Microsatellite analysis of chromosome 3p region in sporadic renal cell carcinomas
β Scribed by Francesca Girolami; Ilaria Passerini; Dorotea Gargano; Sabrina Frusconi; Donata Villari; Giulio Nicita; Francesca Torricelli
- Book ID
- 105700632
- Publisher
- Springer Netherlands
- Year
- 2002
- Tongue
- English
- Weight
- 565 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1219-4956
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Loss of heterozygosity (LOH) at chromosome 8p is associated with the progression of conventional (non-papillary) renal cell carcinomas (RCC). To determine the tumor suppressor gene locus, we carried out a deletion mapping of chromosome 8p at 10 microsatellite loci in 96 RCCs. LOH occurred in 32% of
On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spec
KA, B S , F M ), Sweden Deletions of the short arm of chromosome 3 and associated allele losses have been reported in the majority of sporadic renal cell carcinomas (RCC). O n the basis of the combined cytogenetic and molecular data, it is reasonable to assume that a putative RCC locus, which contri