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Microsatellite analysis reveals deletion of a large region at chromosome 8p in conventional renal cell carcinoma

✍ Scribed by Dietlinde Schullerus; Rolf von Knobloch; Jerzy Chudek; Jutta Herbers; Gyula Kovacs

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 83 KB
Volume: 80
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19990105)80:1<22::aid-ijc5>3.0.co;2-s

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✦ Synopsis

Loss of heterozygosity (LOH) at chromosome 8p is associated with the progression of conventional (non-papillary) renal cell carcinomas (RCC). To determine the tumor suppressor gene locus, we carried out a deletion mapping of chromosome 8p at 10 microsatellite loci in 96 RCCs. LOH occurred in 32% of the tumors. The smallest overlapping region of deletion at chromosome 8p11.2-p23.1 corresponds to approximately 34-cM genetic distance. No small interstitial deletion was seen. Int.

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