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Microsatellite alterations in squamous cell carcinoma of the head and neck — clustering of loss of heterozygosity in a distinct subset

✍ Scribed by I.O.L Ng; L Xiao; K.Y Lam; P.W Yuen; M Ng


Book ID
114393672
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
193 KB
Volume
36
Category
Article
ISSN
1368-8375

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## Abstract ## Background. Microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC) has been reported with a wide range of frequencies. The aim of our study was to disclose the frequency and basis of MSI in HNSCC and to correlate MSI and findings on loss of heterozygosity

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Background. Loss of heterozygosity (LOH) studies have been pivotal in identifying tumor suppressor genes involved in the pathogenesis of a number of cancers. In squamous cell carcinomas of the head and neck region (SCCHN), LOH studies using the Southern blot technique are scarce. Methods. SCCHNs we