Microsatellite instability in squamous cell carcinoma of the head and neck
β Scribed by Field, JK; Kiaris, H; Howard, P; Vaughan, ED; Spandidos, DA; Jones, AS
- Book ID
- 109837107
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 959 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0007-0920
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## Abstract ## Background. Microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC) has been reported with a wide range of frequencies. The aim of our study was to disclose the frequency and basis of MSI in HNSCC and to correlate MSI and findings on loss of heterozygosity
Genomic instability in simple repeated sequences has been observed in several human cancers. We have analyzed 50 squamous cell carcinomas of the head and neck (SCCHN) and 5 pre-malignant severe dysplastic tissues from Indian patient populations for microsatellite instability in 18 different loci spr
Molecular studies have revealed that microsatellite instability and loss of heterozygosity occurred in head-and-neck cancer, suggesting the involvement both of suppressor and of mutator pathways in head-and-neck carcinogenesis. There is evidence for relations between tumor phenotype and clinical par