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MicroRNA as a new player in the cell cycle

✍ Scribed by Dongliang Chen; Mary A. Farwell; Baohong Zhang

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 183 KB
Volume: 225
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.22234

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✦ Synopsis

Abstract

MicroRNAs (miRNAs) are a newly identified class of small regulatory non‐coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein‐coding genes and specific pathways during the cell cycle. This review focuses on the functions of miRNAs in the cell cycle of differentiated cells and embryonic stem (ES) cells. Aberrant expression of these cell‐cycle‐related miRNAs may result in carcinogenesis, revealing the potential of miRNAs as therapeutic targets for clinical purposes. J. Cell. Physiol. 225: 296–301, 2010. © 2010 Wiley‐Liss, Inc.

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