𝔖 Bobbio Scriptorium
✦   LIBER   ✦

MicroRNA: A new player in stem cells

✍ Scribed by Baohong Zhang; Xiaoping Pan; Todd A. Anderson

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
97 KB
Volume
209
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

microRNAs (miRNAs) are an abundant class of endogenous non‐protein‐coding small RNAs, which negatively regulate gene expression at the posttranscriptional level in many developmental and metabolic processes. miRNAs regulate a variety of biological processes, including developmental timing, signal transduction, tissue differentiation and maintenance, disease, and carcinogenesis. Emerging evidence demonstrates that miRNAs also play an essential role in stem cell self‐renewal and differentiation. Some miRNAs are specifically expressed in stem cells, control stem cell self‐renewal, and differentiation through negatively regulating the expression of certain key genes in stem cells. J. Cell. Physiol. 209: 266–269, 2006. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

MicroRNA as a new player in the cell cyc
MicroRNA as a new player in the cell cycle
✍ Dongliang Chen; Mary A. Farwell; Baohong Zhang 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB 👁 1 views

## Abstract MicroRNAs (miRNAs) are a newly identified class of small regulatory non‐coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating ma

Stem cell MicroRNAs in senescence and im
Stem cell MicroRNAs in senescence and immortalization: novel players in cancer therapy
✍ Jose A. Leal; Andrea Feliciano; Matilde E. LLeonart 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB

The molecular etiology of malignancy remains one of the most challenging disease processes under scientific investigation; therefore, improved approaches for their treatment are urgently needed. MicroRNAs are highly conserved nonprotein‐coding RNAs that regulate gene expression. They are involved in

MicroRNAs in embryonic stem cells
MicroRNAs in embryonic stem cells
✍ Yulei Wang; David N. Keys; Janice K. Au-Young; Caifu Chen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB 👁 1 views

## Abstract The unique properties of embryonic stem cells (ESCs) to self‐renew indefinitely or to differentiate to any cell type have great potential for clinical applications in regenerative medicine. MicroRNAs (miRNAs) are emerging as important regulators of post‐transcriptional gene expression a

Identification of microRNAs regulated by
Identification of microRNAs regulated by activin A in human embryonic stem cells
✍ Zong-Yun Tsai; Sher Singh; Sung-Liang Yu; Li-Pin Kao; Bo-Zhi Chen; Bing-Ching Ho 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 336 KB 👁 2 views

## Abstract Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self‐renewal and pluripotency enable hES cells having the potential to provide an un

MicroRNAs play a role in the development
MicroRNAs play a role in the development of human hematopoietic stem cells
✍ Rongxia Liao; Jianguo Sun; Liang Zhang; Guiyu Lou; Min Chen; Dujin Zhou; Zhengta 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB 👁 2 views

## Abstract MicroRNAs (miRNAs) are a class of recently discovered noncoding RNA genes that post‐transcriptionally regulate gene expression. It is becoming clear that miRNAs play an important role in the regulation of gene translation during development. However, in mammals, expression data are prin

Target identification of microRNAs expre
Target identification of microRNAs expressed highly in human embryonic stem cells
✍ Steven Shoei-Lung Li; Sung-Liang Yu; Li-Pin Kao; Zong Yun Tsai; Sher Singh; Bo Z 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

## Abstract MicroRNAs (miRNAs) are noncoding RNAs of approximately 22 nucleotides in length that negatively regulate the post‐transcriptional expression by translational repression and/or destabilization of protein‐coding mRNAs. The impact of miRNAs on protein output was recently shown that althoug