✦ LIBER ✦

MicroRNAs in embryonic stem cells

✍ Scribed by Yulei Wang; David N. Keys; Janice K. Au-Young; Caifu Chen

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 83 KB
Volume: 218
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21607

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The unique properties of embryonic stem cells (ESCs) to self‐renew indefinitely or to differentiate to any cell type have great potential for clinical applications in regenerative medicine. MicroRNAs (miRNAs) are emerging as important regulators of post‐transcriptional gene expression and have been implicated as crucial elements in regulating ESCs. Here, we review recent progresses in characterizing the role of miRNAs in the maintenance and development of ESCs. J. Cell. Physiol. 218: 251–255, 2009. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Target identification of microRNAs expre

Target identification of microRNAs expressed highly in human embryonic stem cells

✍ Steven Shoei-Lung Li; Sung-Liang Yu; Li-Pin Kao; Zong Yun Tsai; Sher Singh; Bo Z 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

## Abstract MicroRNAs (miRNAs) are noncoding RNAs of approximately 22 nucleotides in length that negatively regulate the post‐transcriptional expression by translational repression and/or destabilization of protein‐coding mRNAs. The impact of miRNAs on protein output was recently shown that althoug

Identification of microRNAs regulated by

Identification of microRNAs regulated by activin A in human embryonic stem cells

✍ Zong-Yun Tsai; Sher Singh; Sung-Liang Yu; Li-Pin Kao; Bo-Zhi Chen; Bing-Ching Ho 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 336 KB 👁 2 views

## Abstract Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self‐renewal and pluripotency enable hES cells having the potential to provide an un

Embryonic stem cells

✍ Harold Morowitz 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 41 KB 👁 1 views

DNA methylation in embryonic stem cells

✍ Gulsah Altun; Jeanne F. Loring; Louise C. Laurent 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB

## Abstract Embryonic stem cells (ESCs) are pluripotent, self‐renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in con

MicroRNA: A new player in stem cells

✍ Baohong Zhang; Xiaoping Pan; Todd A. Anderson 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 97 KB 👁 1 views

## Abstract microRNAs (miRNAs) are an abundant class of endogenous non‐protein‐coding small RNAs, which negatively regulate gene expression at the posttranscriptional level in many developmental and metabolic processes. miRNAs regulate a variety of biological processes, including developmental timi

Hematopoietic stem cells: Embryonic begi

Hematopoietic stem cells: Embryonic beginnings

✍ Elaine Dzierzak; Maria-Jose Sanchez; Albrecht Muller; Colin Miles; Alan Holmes; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB 👁 3 views