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Regulating inflammation: ADAM8 – a new player in the game

✍ Scribed by Alexander Zarbock; Jan Rossaint

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
192 KB
Volume
41
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Leukocyte recruitment to sites of inflammation proceeds in a cascade‐like fashion. However, it is less clear how the complex interactions among the different adhesion molecules involved in this process are coordinately regulated. A report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2011. 41: 3436–3442] shows that ADAM8 may participate in the control of the adhesion molecule P‐selectin glycoprotein ligand 1. This finding suggests a new role for ADAM8 in the regulation of inflammatory processes.

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