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Microgranular variant of acute promyelocytic leukemia with normal conventional cytogenetics, negative PML/RARA FISH and positive PML/RARA transcripts by RT-PCR

✍ Scribed by Catherine Lewis; Vijay Patel; Sunil Abhyankar; Da Zhang; Rhett P. Ketterling; Rebecca F. McClure; Diane L. Persons


Book ID
116332629
Publisher
Elsevier
Year
2011
Tongue
English
Weight
81 KB
Volume
204
Category
Article
ISSN
2210-7762

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Identification of PML–RARA rearrangement
✍ Jin-Yeong Han; Kyong-Eun Kim; Kyeong-Hee Kim; Joo-In Park; Jae-Seok Kim πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 581 KB

Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of pa