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Cytogenetically cryptic and FISH-negative PML/RARA rearrangement in acute promyelocytic leukemia detected only by PCR: an exceedingly rare phenomenon

✍ Scribed by Blanco, Elvia Martinez; Curry, Choladda V.; Lu, Xinyan Y.; Sarabia, Stephen F.; Redell, Michele S.; Lopez-Terrada, Dolores H.; Roy, Angshumoy

Book ID: 122199884
Publisher: Elsevier
Year: 2014
Tongue: English
Weight: 98 KB
Volume: 207
Category: Article
ISSN: 2210-7762
DOI: 10.1016/j.cancergen.2014.01.001

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Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of pa