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Acute promyelocytic leukemia with i(17)(q10) on G-banding and PML/RARA rearrangement by RT-PCR without evidence of PML/RARA rearrangement on FISH

✍ Scribed by Jungwon. Huh; H. Moon; H. Chi; W. Chung


Book ID
111415107
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
116 KB
Volume
31
Category
Article
ISSN
1751-5521

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Identification of PML–RARA rearrangement
✍ Jin-Yeong Han; Kyong-Eun Kim; Kyeong-Hee Kim; Joo-In Park; Jae-Seok Kim 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 581 KB

Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of pa