Retinoic acid enhances prostaglandin E2
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Beomsue Kim; Jee-Hyung Lee; Myung-Soon Yang; Ilo Jou; Eun-Hye Joe
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Article
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2008
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John Wiley and Sons
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English
β 403 KB
Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in t