Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia
โ Scribed by Jian Zhang; Shunsuke Fujii; Zhou Wu; Sadayuki Hashioka; Yoshitaka Tanaka; Akiko Shiratsuchi; Yoshinobu Nakanishi; Hiroshi Nakanishi
- Book ID
- 113729754
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 292 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0165-5728
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Prostaglandin E~2~ (PGE~2~) is among the most important mediators involved in neuroinflammatory processes. The final step of its synthesis is regulated by enzymes termed prostaglandin E~2~ synthases (PGES). Three PGES are known, cytosolic (c)PGES, membraneโassociated (m)PGESโ1 and mPGES
Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in t