Hypoxia-inducible factor 1α is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes

Up-regulation of microsomal prostaglandi

Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: Critical roles of the ERK-1/2 and p38 signaling pathways

✍ Kayo Masuko-Hongo; Francis Berenbaum; Lydie Humbert; Colette Salvat; Mary B. Gol 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB 👁 1 views

## Abstract ## Objective Microsomal prostaglandin E synthase 1 (mPGES‐1) is the final enzyme of the cascade that produces prostaglandin E~2~ (PGE~2~), a key actor in arthritis. To study mPGES‐1 synthesis in human cartilage and its regulation by interleukin‐1β (IL‐1β), we used human cartilage and a